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Source: University Medical Center St. Radboud,  Nijmegen, The Netherlands.

22 March 2000. THC 346 stops symptoms of PD in monkeys.

Two neurobiologists from Nijmegen (the Netherlands) have found the compound THC 346 to stop the progression of PD in monkeys completely. Within 3 months a trial will start with PWP. The medicine might also have a positive effect upon ALS and Alzheimers. One of the researchers, Prof. dr. A. Cools of the University Medical Center St Radboud, said the discovery to be every researchers dream. He and his colleague Andringa could not believe it when they saw the effect of THC 346 in tests with rhesus monkeys. Worldwide researchers never before succeeded in actually stopping the progression of PI:, Cools said.

The neurobiologist stressed that the compound does not cure PD. Symptoms that already appeared, will stay. But if PWP have their first symptoms, these symptoms are still minimaL Until now therapy was often delayed because of severe side-effects of the available medication. THC346 makes it possible to stop the progression in an early phase at a level that people still can function quite normal.

Goetz C et al; Neur 2000,54:710-714:

Authors examined 105 early-stage PD patients in the placebo group of a controlled trial of ropinirole (Requip) and found that 1&% of them experienced improvement of PD symptoms.

Schumacher  J et al; Neur 2000;54:1042-1050:

To test safety and efficacy of unilateral embryonic pig cell transplants in PD patients, they followed 12 recipients for a year. They found variable but general improvement in symptoms, no porcine retrovirus and no serious adverse effects.

Science News, 25 Mar 2000;197(news item): Some details about the pig cell transplant trial cited above: In this first trial to establish safety, a relatively small amount of tissue was used. Nevertheless, symptom improvement was "dramatic" in 3 of the 10 advanced-PD subjects, moderate in 3 others, while the remaining 4-were unchanged. A new study with 18 subjects, using 4 times the former amount of tissue, includes a control group getting sham transplants (at first).

Australian Team Reports Stem Cell Breakthrough    By wendy Pugh

MELBOURNE, April 4, 2000 - (Reuters) - Australian scientists said on Tuesday they had succeeded in developing nerve cells from early human embryos (stem cells) which could lead to a cure for Parkinson's disease and a range of other health problems.

We hope that one day we will be able to produce pure populations of specific types of nerve cells that could be used for screening new medicines or for transplantation to correct specific diseases," senior research fellow Martin Pera said. So for instance, if we made dopamine-producing nerve cells, those can potentially be used to treat Parkinson's disease."

From Jeff jones <jpjones@BIGFOOT.COM>
Subject: Care weB pages
It has taken me a healthy group of time to "complete" the CARE Web Pages. The CARE Web Pages
are as complete as any group of pages that continue to be updated . What is CARE? CARE
(Caregivers Are Really Essential) is a sublist of the main PD list, which is especially for caregivers
(CGs) of Parkinsonians (PWPs). The CARE Web Pages are a group of pages drawn from
information shared in messages to the CARE List . There are links to other parkinson or
CareGiver resources. The URL is: http://www.crosswinds.net/~caregivers/index.html

New drug safe for Parkinson's, but not effective by itself

NEW YORK, Apr 24, 2000 (Reuters Health) - Remacemide, a new type of drug for treating Parkinson's disease, has few side effects, but it does not improve the symptoms of the disease when used by itself, according to preliminary findings. However, researchers in the Parkinson Study Group are hopeful that the drug might be effective when combined with levodopa, the drug most commonly used for Parkinson's.